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Nature PubMed Preclinical literature and narrative reviews describe pleiotropic actions including angiogenesis modulation (promotion in healing contexts and proposed inhibition in rodent corneal neovascularization models) and purported cytoprotective effects across diverse injury paradigms, but these remain unconfirmed in controlled human experiments

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GHK-Cu, also known as Copper Tripeptide-1, is a natural growth factor made up of three amino acids and one copper ion

For example, it is possible that the gastro-intestinal side effects experienced when initiating therapy reported in clinical trials explains the low adherence and high discontinuation rates seen in this study, particularly in year 1

This is the primary route used in Russian clinical protocols